In-Silico Modeling of the Mitotic Spindle Assembly Checkpoint
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چکیده
منابع مشابه
In-Silico Modeling of the Mitotic Spindle Assembly Checkpoint
BACKGROUND The Mitotic Spindle Assembly Checkpoint ((M)SAC) is an evolutionary conserved mechanism that ensures the correct segregation of chromosomes by restraining cell cycle progression from entering anaphase until all chromosomes have made proper bipolar attachments to the mitotic spindle. Its malfunction can lead to cancer. PRINCIPLE FINDINGS We have constructed and validated for the hum...
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One of the most awe-inspiring demonstrations in biology is a timelapse video of mitosis viewed with high magnification phase contrast or Nomarski DIC microscopy. From initial chaotic movement comes the orderly alignment of chromosomes at the metaphase plate followed by a flawlessly synchronous splitting of the chromosomes and their gliding separation to the two mitotic poles. Enforcing the timi...
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Thank you for submitting your manuscript for consideration by The EMBO Journal. It has now been evaluated by three referees, whose reports are copied below. Although these reviewers point to the somewhat descriptive nature of the study, they nevertheless consider the main novel observation of apparently autonomous spindle checkpoint inactivation during prolonged mitotic arrest in Aspergillus po...
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Equal segregation of sister chromatids during mitosis requires that pairs of kinetochores establish proper attachment to microtubules emanating from opposite poles of the mitotic spindle. The spindle assembly checkpoint (SAC) protects against errors in segregation by delaying sister separation in response to improper kinetochore-microtubule interactions, and certain checkpoint proteins help to ...
متن کاملMitotic Protein Kinase 1: Role in Spindle Assembly Checkpoint Revisited
Cell division is a highly regulated process and involves sequential activation and deactivation of a number of proteins. Mitotic protein kinase (MPS1) is a part of the spindle assembly checkpoint (SAC) activated during prometaphase and metaphase that prevents chromosome misalignment by arresting the cell in mid-mitosis until all of the chromosomes is properly attached to the mitotic spindle [1]...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2008
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0001555